Role of transforming growth factor-beta 1 in experimental chronic cyclosporine nephropathy.

@article{Shihab1996RoleOT,
  title={Role of transforming growth factor-beta 1 in experimental chronic cyclosporine nephropathy.},
  author={Fuad S. Shihab and Takeshi F Andoh and Amie M. Tanner and N. Noble and Wayne A. Border and Nora Franceschini and W. M. Bennett},
  journal={Kidney international},
  year={1996},
  volume={49 4},
  pages={
          1141-51
        }
}
The pathogenesis of fibrosis in chronic cyclosporine (CsA) nephropathy remains unknown. Since TGF-beta 1 plays a key role in the fibrogenesis of a number of renal diseases, we studied a salt-depleted rat model of chronic CsA nephropathy which shows similarity to the structural and functional lesions described in patients. Pair fed rats were treated with either CsA (15 mg/kg/day s.c.) or an equivalent dose of olive oil and sacrificed at 7 and 28 days. Characteristic histologic changes of… CONTINUE READING
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