Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae. A chemostat culture study.

@article{DaranLapujade2004RoleOT,
  title={Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae. A chemostat culture study.},
  author={Pascale A. S. Daran-Lapujade and Mickel L. A. Jansen and Jean-Marc Daran and Walter M. van Gulik and Johannes H. De Winde and Jack T. Pronk},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 10},
  pages={9125-38}
}
In contrast to batch cultivation, chemostat cultivation allows the identification of carbon source responses without interference by carbon-catabolite repression, accumulation of toxic products, and differences in specific growth rate. This study focuses on the yeast Saccharomyces cerevisiae, grown in aerobic, carbon-limited chemostat cultures. Genome-wide transcript levels and in vivo fluxes were compared for growth on two sugars, glucose and maltose, and for two C2-compounds, ethanol and… CONTINUE READING

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