Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids.

  title={Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids.},
  author={Yurii V. Chinenov and Rebecca Gupte and Jana Dobrovolna and Jamie R Flammer and Bill Liu and Francesco E Michelassi and Inez Rogatsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 29},
Inhibition of cytokine gene expression by the hormone-activated glucocorticoid receptor (GR) is the key component of the anti-inflammatory actions of glucocorticoids, yet the underlying molecular mechanisms remain obscure. Here we report that glucocorticoid repression of cytokine genes in primary macrophages is mediated by GR-interacting protein (GRIP)1, a transcriptional coregulator of the p160 family, which is recruited to the p65-occupied genomic NFκB-binding sites in conjunction with… CONTINUE READING


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Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data. Genes Chromosomes Cancer 51:127–139

  • L Wang
  • Chinenov et al. PNAS | July
  • 2012

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