Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids.

@article{Chinenov2012RoleOT,
  title={Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids.},
  author={Yurii V. Chinenov and Rebecca Gupte and Jana Dobrovolna and Jamie R Flammer and Bill Liu and Francesco E Michelassi and Inez Rogatsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 29},
  pages={11776-81}
}
Inhibition of cytokine gene expression by the hormone-activated glucocorticoid receptor (GR) is the key component of the anti-inflammatory actions of glucocorticoids, yet the underlying molecular mechanisms remain obscure. Here we report that glucocorticoid repression of cytokine genes in primary macrophages is mediated by GR-interacting protein (GRIP)1, a transcriptional coregulator of the p160 family, which is recruited to the p65-occupied genomic NFκB-binding sites in conjunction with… CONTINUE READING

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  • L Wang
  • Chinenov et al. PNAS | July
  • 2012

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