Role of transcription factors in differentiation and reprogramming of hematopoietic cells.

@article{Nakajima2011RoleOT,
  title={Role of transcription factors in differentiation and reprogramming of hematopoietic cells.},
  author={Hideaki Nakajima},
  journal={The Keio journal of medicine},
  year={2011},
  volume={60 2},
  pages={47-55}
}
Differentiation of hematopoietic cells is a sequential process of cell fate decision originating from hematopoietic stem cells (HSCs), allowing multi- or oligopotent progenitors to commit to certain lineages. HSCs are cells that are able to self-renew and repopulate the marrow for the long term. They first differentiate into multipotent progenitors (MPPs), which give rise to common lymphoid progenitors (CLPs) and common myeloid progenitors (CMPs). CMPs then differentiate into granulocyte… CONTINUE READING

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