Role of topoisomerase mutations and efflux in fluoroquinolone resistance of Bacteroides fragilis clinical isolates and laboratory mutants.

@article{Ricci2004RoleOT,
  title={Role of topoisomerase mutations and efflux in fluoroquinolone resistance of Bacteroides fragilis clinical isolates and laboratory mutants.},
  author={Vito Ricci and Marnie L. Peterson and John C. Rotschafer and Hannah M. Wexler and Laura J. V. Piddock},
  journal={Antimicrobial agents and chemotherapy},
  year={2004},
  volume={48 4},
  pages={1344-6}
}
Twelve laboratory mutants and 32 ciprofloxacin-resistant isolates of Bacteroides fragilis were examined for the mechanism(s) of fluoroquinolone resistance. Five mutants had mutations in gyrA. One mutant and two clinical isolates contained a mutation in gyrB. Eight mutants and five clinical isolates accumulated significantly less ciprofloxacin than did wild-type isolates; the mutants and clinical isolates were restored to wild-type characteristics when carbonyl cyanide m-chlorophenylhydrazone… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Efflux-Mediated Drug Resistance in Bacteria

View 9 Excerpts
Highly Influenced

Bacteroides: the good, the bad, and the nitty-gritty.

Clinical microbiology reviews • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…