Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.

@article{Ross1984RoleOT,
  title={Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.},
  author={Wilma Ross and Tony Rowe and Bonnie S. Glisson and Jack C. Yalowich and Li Liu},
  journal={Cancer research},
  year={1984},
  volume={44 12 Pt 1},
  pages={5857-60}
}
Epipodophyllotoxins are an important new class of anticancer agents which include the compounds VM-26 (teniposide) and VP-16 (etoposide). The mechanism of action of these drugs appears to involve production of DNA single- and double-strand breaks by virtue of a temperature-sensitive interaction between drug and a heat-labile intranuclear component. We now report evidence indicating that type II topoisomerase is the likely intracellular target for the DNA strand-breaking effects of the… CONTINUE READING