Role of tissue factor in feto-maternal development: a xiphos.

  title={Role of tissue factor in feto-maternal development: a xiphos.},
  author={Guillermina Girardi},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={9 2},
In this review, the dual role of tissue factor (TF) in pregnancy is described. On the one hand, TF is required for embryonic and placental development in a successful pregnancy, and on the other hand, pathologic expression of TF can lead to serious pregnancy complications in humans and mice. Human studies show increased TF levels in plasma, amniotic fluid and and/or placentas of abnormal pregnancies affected by miscarriages, preterm birth, or pre-eclampsia. Interestingly, using two mouse models… CONTINUE READING