Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies.

@article{Seshan2009RoleOT,
  title={Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies.},
  author={S Venkata Seshan and Claus-Werner Franzke and Patricia Redecha and Marc Monestier and Nigel Mackman and Guillermina Girardi},
  journal={Blood},
  year={2009},
  volume={114 8},
  pages={1675-83}
}
Using different mouse monoclonal and human antiphospholipid (aPL) antibodies, we developed a new animal model of renal injury that shares many features with thrombotic microangiopathy (TMA). We found that more than 1 mechanism/signaling pathway is involved in glomerular injury induced by aPL antibodies in this model. Both complement-dependent and complement-independent pathways were identified that lead to glomerular endothelial cell damage and renal function impairment. We also found that C5a… CONTINUE READING