Role of thyroid hormone in stimulating liver repopulation in the rat by transplanted hepatocytes.

@article{Oren1999RoleOT,
  title={Role of thyroid hormone in stimulating liver repopulation in the rat by transplanted hepatocytes.},
  author={Ran Oren and Mariana D. Dabeva and Anthony N Karnezis and Petko M. Petkov and Richard A Rosencrantz and J P Sandhu and Steven F. Moss and Shu De Wang and E Hurston and Ezio Laconi and Peter R. Holt and Swan N. Thung and Li-Min Zhu and David A. Shafritz},
  journal={Hepatology},
  year={1999},
  volume={30 4},
  pages={903-13}
}
Recently, we reported near-complete repopulation of the rat liver by transplanted hepatocytes using retrorsine (RS), a pyrrolizidine alkaloid that alkylates cellular DNA and blocks proliferation of resident hepatocytes, followed by transplantation of normal hepatocytes in conjunction with two-thirds partial hepatectomy (PH). Because two-thirds PH is not feasible for use in humans, in the present study, we evaluated the ability of thyroid hormone (triiodothyronine [T(3)]), a known hepatic… CONTINUE READING

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