Role of thyroid hormone deiodination in the hypothalamus.

  title={Role of thyroid hormone deiodination in the hypothalamus.},
  author={Ronald M. Lechan and Csaba Fekete},
  journal={Thyroid : official journal of the American Thyroid Association},
  volume={15 8},
Iodothyronine deiodinases (D1, D2, and D3) comprise a family of selenoproteins that are involved in the conversion of thyroxine (T(4)) to active triiodothyronine (T(3)), and also the inactivation of both thyroid hormones. The deiodinase enzymes are of critical importance for the normal development and function of the central nervous system. D1 is absent from the human brain, suggesting that D2 and D3 are the two main enzymes involved in the maintenance of thyroid hormone homeostasis in the… CONTINUE READING