Role of thromboxane in retinal microvascular degeneration in oxygen-induced retinopathy.

@article{Beauchamp2001RoleOT,
  title={Role of thromboxane in retinal microvascular degeneration in oxygen-induced retinopathy.},
  author={Miriam H Beauchamp and Ana Katherine Mart{\'i}nez-Berm{\'u}dez and François Gobeil and Anne Marilise Marrache and Xiuyun Hou and Giovanna Speranza and Daniel Abran and Christiane Quiniou and Pierre Lachapelle and Joseph Roberts and Guillermina Almazan and D. Ramesh Varma and Sylvain Chemtob},
  journal={Journal of applied physiology},
  year={2001},
  volume={90 6},
  pages={2279-88}
}
Microvascular degeneration is an important event in oxygen-induced retinopathy (OIR), a model of retinopathy of prematurity. Because oxidant stress abundantly generates thromboxane A2 (TxA2), we tested whether TxA2 plays a role in retinal vasoobliteration of OIR and contributes to such vascular degeneration by direct endothelial cytotoxicity. Hyperoxia-induced retinal vasoobliteration in rat pups (80% O2 exposure from postnatal days 5-14) was associated with increased TxB2 generation and was… CONTINUE READING