Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice.

@article{Katagiri2004RoleOT,
  title={Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice.},
  author={Hiroyuki Katagiri and Yoshiya Ito and Ken-ichiro Ishii and Izumi Nagata M. D. Kentaro Hayashi and Makoto Suematsu and Shohei Yamashina and Takahiko Murata and Shuh Narumiya and Akira Kakita and Masataka C Majima},
  journal={Hepatology},
  year={2004},
  volume={39 1},
  pages={139-50}
}
Although thromboxanes (TXs), whose synthesis is regulated by cyclooxygenase (COX), have been suggested to promote inflammation in the liver, little is known about the role of TXA(2) in leukocyte endothelial interaction during endotoxemia. The present study was conducted to investigate the role of TXA(2) as well as that of COX in lipopolysaccharide (LPS)-induced hepatic microcirculatory dysfunction in male C57Bl/6 mice. We observed during in vivo fluorescence microscopic study that LPS caused… CONTINUE READING

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