Role of thrombospondin 1 in macrophage inflammation in dysferlin myopathy.

@article{Luna2010RoleOT,
  title={Role of thrombospondin 1 in macrophage inflammation in dysferlin myopathy.},
  author={Noemi De Luna and Eduard Gallardo and Corinne Sonnet and B{\'e}n{\'e}dicte Chazaud and Ra{\'u}l Dom{\'i}nguez-Perles and Xavier Su{\'a}rez-Calvet and Romain Kroum Gherardi and Isabel Illa},
  journal={Journal of neuropathology and experimental neurology},
  year={2010},
  volume={69 6},
  pages={643-53}
}
Muscle inflammation can be a prominent feature in several muscular dystrophies. In dysferlin myopathy, it is mainly composed of macrophages. To understand the origin of inflammation in dysferlin-deficient muscle, we analyzed soluble factors involved in monocyte chemotaxis released by myoblasts and myotubes from control and dysferlinopathy patients using a transwell system. Dysferlin-deficient myotubes released more soluble factors involved in monocyte chemotaxis compared with controls (p < 0… CONTINUE READING

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