Role of thrombospondin-1-derived peptide, 4N1K, in FGF-2-induced angiogenesis.

  title={Role of thrombospondin-1-derived peptide, 4N1K, in FGF-2-induced angiogenesis.},
  author={Shintaro Kanda and Tadahisa Shono and Bianca Tomasini-Johansson and Peter Klint and Yoshinari Saito},
  journal={Experimental cell research},
  volume={252 2},
Angiogenesis involves proliferation of capillary endothelial cells and formation of lumen-containing tube-like structures. A recently established murine brain capillary endothelial cell line, IBE, can either proliferate or form tube-like structures (i.e., differentiate) in response to fibroblast growth factor-2 (FGF-2), dependent on the culture conditions. The 4N1K peptide (KRFYVVMWKK), which is derived from the C-terminal cell-binding domain of thrombospondin-1 (TSP-1), inhibited tube… CONTINUE READING
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