Role of thrombin compared with factor Xa in the procoagulant activity of whole blood clots.

@article{Prager1995RoleOT,
  title={Role of thrombin compared with factor Xa in the procoagulant activity of whole blood clots.},
  author={N A Prager and Dana Abendschein and Clarence McKenzie and Paul R. Eisenberg},
  journal={Circulation},
  year={1995},
  volume={92 4},
  pages={
          962-7
        }
}
BACKGROUND Thrombi are known to induce activation of the coagulation system, which may be a mechanism for progression of thrombosis and its recurrence after thrombolysis. This study was designed to characterize the relative role of thrombin and activated factor X (factor Xa) as mediators of procoagulant activity of whole blood clots in blood and plasma. METHODS AND RESULTS Clots formed from human blood were incubated in recalcified (25 mmol/L CaCl2) citrated plasma or nonanticoagulated blood… CONTINUE READING
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