Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis.

  title={Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis.},
  author={David C J Howell and Geoffrey J. Laurent and Rachel C. Chambers},
  journal={Biochemical Society transactions},
  volume={30 2},
Pulmonary fibrosis is the end stage of a heterogeneous group of disorders and is characterized by the excessive deposition of extracellular matrix proteins within the pulmonary interstitium. There is increasing evidence from a number of studies that activation of the coagulation cascade, with the resultant generation of coagulation proteases, plays a central role in fibrotic lung disease that is associated with acute and chronic lung injury. Consistent with this finding, levels of thrombin are… 

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  • R. Chambers
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Fibrinolysis inhibition in acute respiratory distress syndrome.

  • W. KirschsteinD. Heene
  • Medicine, Biology
    Scandinavian journal of clinical and laboratory investigation. Supplementum
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