Role of threonine 101 on the stability of the heme active site of cytochrome P450cam: multiwavelength circular dichroism studies.

@article{Manna2006RoleOT,
  title={Role of threonine 101 on the stability of the heme active site of cytochrome P450cam: multiwavelength circular dichroism studies.},
  author={Soumen Kanti Manna and Shyamalava Mazumdar},
  journal={Biochemistry},
  year={2006},
  volume={45 42},
  pages={12715-22}
}
The role of the threonine 101 residue that resides close to the heme propionic acid side chain of cytochrome P450cam on the conformational properties of the active site of the enzyme has been investigated by circular dichroism (CD) spectroscopy. Site-specific mutation of the threonine by valine has been carried out that does not affect the size of the… CONTINUE READING