Role of thiols in the presentation of a snake toxin to murine T cells.

@article{Maillere1993RoleOT,
  title={Role of thiols in the presentation of a snake toxin to murine T cells.},
  author={Bernard Maillere and J{\"o}el Cotton and Gilles Mourier and Michel L{\'e}onetti and Sabine Leroy and Andr{\'e} M{\'e}nez},
  journal={Journal of immunology},
  year={1993},
  volume={150 12},
  pages={5270-80}
}
We isolated and characterized two T hybridomas specific for a highly stable snake toxic protein. One hybridoma, called T1C9, is I-E(d)-restricted and stimulated by both the native and reduced and carboxymethylated (RCM) toxins and by synthetic fragments containing the region 24-36. The other hybridoma, called T1B2, is I-A(d)-restricted and stimulated by the native toxin, only. Neither the RCM toxin nor any of the initial synthetic peptides used in our study could stimulate it. We show that this… CONTINUE READING

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