Role of thiol-complex formation in 2-hydroxyethyl- methacrylate-induced toxicity in vitro.

@article{Samuelsen2011RoleOT,
  title={Role of thiol-complex formation in 2-hydroxyethyl- methacrylate-induced toxicity in vitro.},
  author={J. T. Samuelsen and H. Kopperud and J. Holme and I. S. Dragland and T. Christensen and J. Dahl},
  journal={Journal of biomedical materials research. Part A},
  year={2011},
  volume={96 2},
  pages={
          395-401
        }
}
Methacrylate monomers that are found to leach from cured resin-based dental materials induce biological effects in vitro. The underlying mechanisms have not been fully elucidated although involvement of increased cellular reactive oxygen species (ROS) and DNA-damage has been suggested. In this in vitro study we have elucidated the impact of a commonly used methacrylate monomer, HEMA, on the level and oxidation state of cellular glutathione, intracellular ROS level, as well as the formation of… Expand
41 Citations
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The dental monomer 2-hydroxyethyl methacrylate (HEMA) causes transcriptionally regulated adaptation partially initiated by electrophilic stress.
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