Role of thiol/disulfide exchange in newcastle disease virus entry.

@article{Jain2009RoleOT,
  title={Role of thiol/disulfide exchange in newcastle disease virus entry.},
  author={Surbhi Jain and Lori W. McGinnes and Trudy G. Morrison},
  journal={Journal of virology},
  year={2009},
  volume={83 1},
  pages={241-9}
}
Newcastle disease virus (NDV) entry into host cells is mediated by the hemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins. We previously showed that production of free thiols in F protein is required for membrane fusion directed by F protein (S. Jain et al., J. Virol. 81:2328-2339, 2007). In the present study we evaluated the oxidation state of F protein in virions and virus-like particles and its relationship to activation of F protein by HN protein, F protein conformational… CONTINUE READING

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