Role of thermo TRPA1 and TRPV1 channels in heat, cold, and mechanical nociception of rats.

@article{Nozadze2016RoleOT,
  title={Role of thermo TRPA1 and TRPV1 channels in heat, cold, and mechanical nociception of rats.},
  author={Ivliane Nozadze and N. J. Tsiklauri and Gulnazi Gurtskaia and Merab G Tsagareli},
  journal={Behavioural pharmacology},
  year={2016},
  volume={27 1},
  pages={29-36}
}
A sensitive response of the nervous system to changes in temperature is of predominant importance for homeotherms to maintain a stable body temperature. A number of temperature-sensitive transient receptor potential (TRP) ion channels have been studied as nociceptors that respond to extreme temperatures and harmful chemicals. Recent findings in the field of pain have established a family of six thermo-TRP channels (TRPA1, TRPM8, TRPV1, TRPV2, TRPV3, and TRPV4) that exhibit sensitivity to… CONTINUE READING
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