Role of the ventral subiculum in stress integration.

  title={Role of the ventral subiculum in stress integration.},
  author={James P Herman and Nancy K Mueller},
  journal={Behavioural brain research},
  volume={174 2},
The mammalian subiculum plays a prominent role in inhibition of the hypothalamo-pituitary-adrenocortical (HPA) axis. Lesion and stimulation studies indicate that the hippocampus, acting via output neurons of the ventral subiculum, acts to attenuate stress-induced glucocorticoid release. Lesions of the ventral subiculum enhance glucocorticoid secretion following psychogenic, but not systemic stressors, indicating that the influence of this structure on the HPA system is stressor-specific… CONTINUE READING
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