Role of the unfolded protein response (UPR) in cataract formation.

  title={Role of the unfolded protein response (UPR) in cataract formation.},
  author={Kengo Ikesugi and Ryoko Yamamoto and Michael L. Mulhern and Toshimichi Shinohara},
  journal={Experimental eye research},
  volume={83 3},
Cataract is a multifactorial disease, and a large variety of stressors induce cataracts. Many cataractogenic stressors and endoplasmic reticulum (ER) stressors induce the unfolded protein response (UPR) in various cell types. The UPR is known to produce reactive oxygen species (ROS) prior to the inducement of apoptosis. We investigated whether ER stressors induce the UPR in lens epithelial cells (LECs) or whole rat lenses. Our results showed that higher levels of ER stressors activated Bip… CONTINUE READING

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