Role of the ubiquitin-proteasome pathway in downregulation of the gap-junction protein Connexin43 by TNF-{alpha} in human corneal fibroblasts.

@article{Kimura2010RoleOT,
  title={Role of the ubiquitin-proteasome pathway in downregulation of the gap-junction protein Connexin43 by TNF-\{alpha\} in human corneal fibroblasts.},
  author={Kazuhiro Kimura and Teruo Nishida},
  journal={Investigative ophthalmology & visual science},
  year={2010},
  volume={51 4},
  pages={1943-7}
}
Purpose. Fibroblasts in the corneal stroma communicate with each other through gap junctions and form a three-dimensional-network structure. The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) downregulates the gap-junction protein connexin43 (Cx43) and thereby inhibits gap-junctional intercellular communication (GJIC) in corneal fibroblasts. The authors examined the role of the ubiquitin-proteasome system in the TNF-alpha-induced degradation of Cx43 in these cells. Methods… CONTINUE READING

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