Role of the ubiquitin/proteasome system in regulated protein degradation in Saccharomyces cerevisiae.

@article{Smith1996RoleOT,
  title={Role of the ubiquitin/proteasome system in regulated protein degradation in Saccharomyces cerevisiae.},
  author={Sue E Smith and Manfred Koegl and Stephan Jentsch},
  journal={Biological chemistry},
  year={1996},
  volume={377 7-8},
  pages={
          437-46
        }
}
Selective degradation of proteins in eukaryotes is mediated primarily by the ubiquitin system in conjunction with the 26S proteasome. The yeast Saccharomyces cerevisiae has proved a powerful model system to study protein degradation in vivo. Biochemical and genetic studies complemented by the sequence analysis of the entire yeast genome have identified more than 70 genes presumed to function in the ubiquitin/proteasome system. Moreover, a number of physiological substrates of the ubiquitin… CONTINUE READING

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