Role of the tuberculum olfactorium in stereotyped behaviour induced by apomorphine in the rat

  title={Role of the tuberculum olfactorium in stereotyped behaviour induced by apomorphine in the rat},
  author={Gerald M. Mckenzie},
  • G. Mckenzie
  • Published 2004
  • Biology, Psychology
  • Psychopharmacologia
Bilateral ablation of the tuberculum olfactorium markedly reduced stereotyped behaviour following apomorphine treatment in the rat. Bilateral dissection of the olfactory bulb or large bilateral lesions in the nucleus caudatus putamen did not significantly affect the stereotyped behaviour. It is concluded that an intact tuberculum olfactorium is essential for the induction of stereotyped behaviour by apomorphine. 

The role of forebrain dopamine systems in amphetamine induced stereotyped behavior in the rat

The results demonstrate that amphetamine is an indirect sympathomimetic agent and further emphasize the critical role of the dopaminergic nigrostriatal pathway in amphetamine induced stereotypy.

Cholinergic antagonism of methylphenidate-induced stereotyped behavior

Physostigmine abolished rat stereotyped gnawing behavior and methylphenidate prevented the occurrence of stereotyped Gnawing Behavior in rats pretreated with methylscopolamine.

Antagonism of apomorphine- and d-amphetamine-induced stereotyped behaviour by injection of low doses of haloperidol into the caudate nucleus and the nucleus accumbens

Neither administration of the local anesthetic agent procaine into the caudate nucleus nor into the nucleus accumbens did significantly reduce apomorphine-induced stereotyped behaviour, but the possible way in which haloperidol, following central administration, influences stereotyping behaviour is discussed.

Changes in dopamine agonist and antagonist activity floowing temporary inactivation of the neostriatum

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Does chronic morphine treatment induce a supersensitivity of dopamine receptors in rat brain?

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Analysis of climbing suggests that this response is comprised of two (previously unidentified) fundamental effects of apomorphine: snout contact fixation and bodywise forward progression, and an inverse relation between oral activity and climbing.

GABA blockade, dopamine and schizophrenia: Experimental studies in the cat

The effects of blocking putative GABA inhibition on dopamine cells of origin in ventral tegmental area and substantia nigra have been examined in freely moving cats with chronically implanted cannulas and recording electrodes and to evidence of dopamine excess or hypersensitivity in limbic striatum in patients with schizophrenic disorders is considered.

The site and mode of action of ET495 for the mediation of stereotyped behaviour in the rat

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Possible GABA-mediated control of dopamine-dependent behavioural effects from the nucleus accumbens of the rat

A possible GABA-mediated control of dopaminergic mechanisms in the nucleus accumbens is suggested, and the possible site of interaction discussed is suggested.



Site of action of dopamine and apomorphine on compulsive gnawing behaviour in rats

Es wird die Relation von Struktur und Wirkung zwischen Dopamin und Apomorphin beim Zwangsnagen der Ratte, nach stereotaktischer Implantation der beiden Substanzen besprochen.

Evidence for dopamine receptor stimulation by apomorphine

Supporting evidence for apomorphine acts on the dopamine receptors whereas amphetamine acts by releasing dopamine is given by further functional, biochemical and histochemical studies.

Relation between the action of dopamine and apomorphine and their O-methylated derivatives upon the CNS

SummaryThe syndrome of gnaw-compulsion was studied in rats providing evidence for a structure-effect relationship between the alcaloid apomorphine and the normal metabolite in the brain, dopamine.The

Acceleration of the cerebral dopamine turnover by chlorpromazine

Die durch Vorbehandlung mit einem kurzwirkenden Monoaminfreisetzer erhöhte endogene HVS zeigt nach Chlorpromazin keinen verzögerten Abfall.

A quantitative study on the nigro-neostriatal dopamine neuron system in the rat.

In a combined biochemical and histochemical investigation the following quantitative data on a unilateral nigro-neostriatal dopamine neuron system in the rat have been obtained or calculated. — The

The significance of dopamine-receptor blockade for the mechanism of action of neuroleptic drugs.

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