Role of the tuberculum olfactorium in stereotyped behaviour induced by apomorphine in the rat

@article{Mckenzie2004RoleOT,
  title={Role of the tuberculum olfactorium in stereotyped behaviour induced by apomorphine in the rat},
  author={Gerald M. Mckenzie},
  journal={Psychopharmacologia},
  year={2004},
  volume={23},
  pages={212-219}
}
  • G. Mckenzie
  • Published 2004
  • Biology, Psychology
  • Psychopharmacologia
Bilateral ablation of the tuberculum olfactorium markedly reduced stereotyped behaviour following apomorphine treatment in the rat. Bilateral dissection of the olfactory bulb or large bilateral lesions in the nucleus caudatus putamen did not significantly affect the stereotyped behaviour. It is concluded that an intact tuberculum olfactorium is essential for the induction of stereotyped behaviour by apomorphine. 

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References

SHOWING 1-10 OF 13 REFERENCES

Site of action of dopamine and apomorphine on compulsive gnawing behaviour in rats

Es wird die Relation von Struktur und Wirkung zwischen Dopamin und Apomorphin beim Zwangsnagen der Ratte, nach stereotaktischer Implantation der beiden Substanzen besprochen.

Evidence for dopamine receptor stimulation by apomorphine

TLDR
Supporting evidence for apomorphine acts on the dopamine receptors whereas amphetamine acts by releasing dopamine is given by further functional, biochemical and histochemical studies.

Relation between the action of dopamine and apomorphine and their O-methylated derivatives upon the CNS

SummaryThe syndrome of gnaw-compulsion was studied in rats providing evidence for a structure-effect relationship between the alcaloid apomorphine and the normal metabolite in the brain, dopamine.The

Acceleration of the cerebral dopamine turnover by chlorpromazine

TLDR
Die durch Vorbehandlung mit einem kurzwirkenden Monoaminfreisetzer erhöhte endogene HVS zeigt nach Chlorpromazin keinen verzögerten Abfall.

A quantitative study on the nigro-neostriatal dopamine neuron system in the rat.

In a combined biochemical and histochemical investigation the following quantitative data on a unilateral nigro-neostriatal dopamine neuron system in the rat have been obtained or calculated. — The

The significance of dopamine-receptor blockade for the mechanism of action of neuroleptic drugs.

  • J. V. van Rossum
  • Psychology
    Archives internationales de pharmacodynamie et de therapie
  • 1966

And6n, N.-E.: Effects of apomorphine and amphetamine on schedule-controlled behaviour: reversal of tetrabenazine suppression and dopaminergie correlates

  • Europ. J. Pharmacol
  • 1969