Role of the transmembrane domain in SNARE protein mediated membrane fusion: peptide nucleic acid/peptide model systems.

@article{Wehland2016RoleOT,
  title={Role of the transmembrane domain in SNARE protein mediated membrane fusion: peptide nucleic acid/peptide model systems.},
  author={Jan-Dirk Wehland and Antonina S. Lygina and Pawan Kumar and Samit Guha and Barbara E. Hubrich and Reinhard Jahn and Ulf Diederichsen},
  journal={Molecular bioSystems},
  year={2016},
  volume={12 9},
  pages={2770-6}
}
Fusion of synaptic vesicles with the presynaptic plasma membrane is mediated by Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein Receptor proteins also known as SNAREs. The backbone of this essential process is the assembly of SNAREs from opposite membranes into tight four helix bundles forcing membranes in close proximity. With model systems resembling SNAREs with reduced complexity we aim to understand how these proteins work at the molecular level. Here, peptide nucleic… CONTINUE READING