Role of the tissue factor pathway in synovial inflammation.

  title={Role of the tissue factor pathway in synovial inflammation.},
  author={Nathalie Busso and Carole Morard and Roberto Salvi and Veronique P{\'e}clat and Alexander So},
  journal={Arthritis and rheumatism},
  volume={48 3},
OBJECTIVE Clinical and experimental evidence suggests that extravascular fibrin deposition in arthritic joints is prominent and deleterious. The aim of this study was to investigate the contributions of tissue factor (TF) and its inhibitor, TF pathway inhibitor (TFPI), in arthritis. METHODS Synovial tissue specimens obtained from 10 patients with rheumatoid arthritis (RA) and 12 patients with osteoarthritis (OA) were scored histologically for inflammation and fibrin content. TF and TFPI… CONTINUE READING
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