Role of the thrombin receptor in development and evidence for a second receptor

@article{Connolly1996RoleOT,
  title={Role of the thrombin receptor in development and evidence for a second receptor},
  author={Andrew J. Connolly and Hiroaki Ishihara and Mark L. Kahn and Robert V Farese and Shaun R Coughlin},
  journal={Nature},
  year={1996},
  volume={381},
  pages={516-519}
}
THROMBIN, a coagulation protease generated at sites of vascular injury, activates platelets, endothelial cells, leukocytes and mesenchymal cells1,2. A G-protein-coupled receptor that is proteolytically activated by thrombin3 is a target for drug development aimed at blocking thrombosis, inflammation and proliferation. Here we show that although disruption of the thrombin receptor (tr) gene in mice causes about half of the tr-/- embryos to die at embryonic day 9–10, half survive to become… CONTINUE READING

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