Role of the sulfonylurea receptor in regulating human adipocyte metabolism.

@article{Shi1999RoleOT,
  title={Role of the sulfonylurea receptor in regulating human adipocyte metabolism.},
  author={Hang Shi and Naima Moustaid-Moussa and William O. Wilkison and Michael B Zemel},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1999},
  volume={13 13},
  pages={1833-8}
}
A regulatory role for intracellular Ca2+ ([Ca2+]i) in adipocyte lipogenesis, lipolysis and triglyceride accumulation has been demonstrated. Compounds acting on the pancreatic sulfonylurea receptor (SUR) to increase (e.g., glibenclamide) or decrease (e.g., diazoxide) [Ca2+]i cause corresponding increases and decreases in weight gain. However, these weight… CONTINUE READING