Role of the substantia nigra pars reticulata in sensorimotor gating, measured by prepulse inhibition of startle in rats.

@article{Koch2000RoleOT,
  title={Role of the substantia nigra pars reticulata in sensorimotor gating, measured by prepulse inhibition of startle in rats.},
  author={Michael Koch and Markus Fendt and Beate D. Kretschmer},
  journal={Behavioural brain research},
  year={2000},
  volume={117 1-2},
  pages={153-62}
}
The substantia nigra pars reticulata (SNR) is one of the major output nuclei of the basal ganglia. It connects the dorsal and ventral striatum with the thalamus, superior colliculus and pontomedullary brainstem. The SNR is therefore in a strategic position to regulate sensorimotor behavior. We here assessed the effects of SNR lesions on prepulse inhibition (PPI) of the acoustic startle response (ASR), stereotypy and locomotion in drug-free rats, as well as after systemic administration of the… CONTINUE READING
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