Role of the spleen in the development of steatohepatitis in high-fat-diet-induced obese rats.

Abstract

Obesity is considered a systemic low-grade inflammatory state. Although the spleen is the main immune organ with a close anatomical relationship with the liver, its role in the progression of fatty liver disease remains uncertain. Therefore, we sought to clarify the functional role of the spleen in the development of steatohepatitis in high-fat (HF)-diet… (More)
DOI: 10.1258/ebm.2011.011230

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