Role of the small GTPase Rho1 in cell wall integrity, stress response, and pathogenesis of Aspergillus fumigatus.

@article{Zhang2018RoleOT,
  title={Role of the small GTPase Rho1 in cell wall integrity, stress response, and pathogenesis of Aspergillus fumigatus.},
  author={Xi Zhang and Xiaodong Jia and Shuguang Tian and Changjian Zhang and Zhongyi Lu and Yong Chen and Fangyan Chen and Zongwei Li and Xueting Su and Xuelin Han and Yansong Sun and Li Han},
  journal={Fungal genetics and biology : FG & B},
  year={2018},
  volume={120},
  pages={
          30-41
        }
}
Aspergillus fumigatus is a major pathogen of invasive pulmonary aspergillosis. The small GTPase, Rho1, of A. fumigatus is reported to comprise a potential regulatory subunit of β-1,3-glucan synthase and is indispensable for fungal viability; however, the role of AfRho1 on the growth, cell wall integrity, and pathogenesis of A. fumigatus is still poorly understood. We constructed A. fumigatus mutants with conditional- and overexpression of Rho1 and found that defects of AfRho1 expression led to… CONTINUE READING
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