Role of the signal peptide in the synthesis and processing of the glucagon-like peptide-1 receptor.


BACKGROUND AND PURPOSE The glucagon-like peptide-1 receptor (GLP-1R) belongs to Family B of the G protein-coupled receptor superfamily and is a target for treatment of type 2 diabetes. Family B G protein-coupled receptors contain a putative N-terminal signal peptide, but its role in receptor synthesis and trafficking are unclear. Further, the signal peptide… (More)
DOI: 10.1111/j.1476-5381.2009.00517.x

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