Role of the serine-rich surface glycoprotein GspB of Streptococcus gordonii in the pathogenesis of infective endocarditis.

@article{Xiong2008RoleOT,
  title={Role of the serine-rich surface glycoprotein GspB of Streptococcus gordonii in the pathogenesis of infective endocarditis.},
  author={Yan Xiong and Barbara A. Bensing and Arnold S. Bayer and Henry F. Chambers and Paul M Sullam},
  journal={Microbial pathogenesis},
  year={2008},
  volume={45 4},
  pages={297-301}
}
The direct binding of bacteria to platelets is a central interaction in the pathogenesis of infective endocarditis. GspB is a serine-rich, cell wall glycoprotein of Streptococcus gordonii that mediates the binding of this organism to human platelets in vitro. To assess the contribution of this adhesin to the pathogenesis of endocarditis, we compared the virulence of S. gordonii M99 (which expresses GspB) with an isogenic, gspB mutant (PS846) in two rat models of endovascular infection. In the… CONTINUE READING
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