Role of the second extracellular loop of human C3a receptor in agonist binding and receptor function.

@article{Chao1999RoleOT,
  title={Role of the second extracellular loop of human C3a receptor in agonist binding and receptor function.},
  author={Taina H. Chao and Julia A. Ember and Ming Wang and Yves Bayon and Tony E. Hugli and Richard D Ye},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 14},
  pages={
          9721-8
        }
}
The C3a anaphylatoxin receptor (C3aR) is a G protein-coupled receptor with an unusually large second extracellular loop (e2 loop, approximately 172 amino acids). To determine the function of this unique structure, chimeric and deletion mutants were prepared and analyzed in transfected RBL-2H3 cells. Whereas replacement of the C3aR N-terminal segment with that from the human C5a receptor had minimal effect on C3a binding, substitution of the e2 loop with a smaller e2 loop from the C5a receptor… CONTINUE READING
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