Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors.

@article{Olh1994RoleOT,
  title={Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors.},
  author={M. Ol{\'a}h and Kenneth A. Jacobson and Gary L. Stiles},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 40},
  pages={24692-8}
}
Adenosine receptor (AR) agonists and antagonists are approximately 100-fold and 100,000-fold, respectively, more potent at the bovine A1AR as compared to the rat A3AR. To determine regions of ARs involved in ligand recognition, chimeric receptors composed of bovine A1AR and rat A3AR sequence were constructed and their ligand binding properties examined following expression in COS-7 cells. Substitutions of the second extracellular loop or a region encompassing transmembrane domains 6 and 7 of… CONTINUE READING

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