Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits.

@article{Cheung1994RoleOT,
  title={Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits.},
  author={Ambrose L. Cheung and Michael R Yeaman and Paul M Sullam and Mallory D. Witt and Arnold S. Bayer},
  journal={Infection and immunity},
  year={1994},
  volume={62 5},
  pages={1719-25}
}
A regulatory locus on the Staphylococcus aureus chromosome, designated sar, is involved in the expression of cell wall proteins, some of which are potentially important in the pathogenesis of endocarditis. For instance, mutant 11D2 (sar::Tn917LTV1) was found to bind substantially less to matrix proteins (i.e., fibrinogen and fibronectin) than parent strain… CONTINUE READING