Role of the ribosome in protein folding.

@article{Das2008RoleOT,
  title={Role of the ribosome in protein folding.},
  author={Debasis Das and Anindita Das and Dibyendu Samanta and Jaydip Ghosh and Santanu Dasgupta and Arpita Bhattacharya and Arunima Basu and Suparna Sanyal and Chanchal Das Gupta},
  journal={Biotechnology journal},
  year={2008},
  volume={3 8},
  pages={999-1009}
}
In all organisms, the ribosome synthesizes and folds full length polypeptide chains into active three-dimensional conformations. The nascent protein goes through two major interactions, first with the ribosome which synthesizes the polypeptide chain and holds it for a considerable length of time, and then with the chaperones. Some of the chaperones are found in solution as well as associated to the ribosome. A number of in vitro and in vivo experiments revealed that the nascent protein folds… CONTINUE READING
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Substrate specificity of the DnaK chaperone determined 0999_200800098_Debasis.qxd 08.08.2008

  • S. Rüdiger, L. Germeroth, J. Schneider-Mergener, B. Bukau
  • EMBO J. 1997,
  • 2008
1 Excerpt

Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy

  • Hsu, D S.T., P. Fucini, L. D. Cabrita, H Launay
  • Proc. Natl. Acad. Sci. USA
  • 2007
1 Excerpt

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