Role of the renin-angiotensin system in the pathogenesis of severe hypertension in rats.


Plasma renin levels axe elevated in accelerated or malignant hypertension. To see if this increase of renin is a concurrent phenomenon or a pathogenetic factor in the increase of blood pressure, severe hypertension was produced in rats by occluding the aorta between die origins of the renal arteries. Eight days later, these animals had developed severe… (More)


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