Role of the renin-angiotensin-aldosterone system in the regulation of plasma potassium in chronic renal disease.

@article{Weidmann1975RoleOT,
  title={Role of the renin-angiotensin-aldosterone system in the regulation of plasma potassium in chronic renal disease.},
  author={P. Weidmann and Morton H. Maxwell and P Elaine Rowe and Rachel L Winer and Shaul G. Massry},
  journal={Nephron},
  year={1975},
  volume={15 1},
  pages={35-49}
}
The relationship between plasma potassium concentration and the renin-angiotensin-aldosterone system was evaluated in ten patients with chronic renal failure (creatinine clearance 10-56 ml/min). Under basal conditions and following various stimulation maneuvers, normokalemic patients demonstrated normal plasma renin and aldosterone levels. Five of six patients with hyperkalemia had diminished function of the renin-angiotensin-aldosterone system; their ability to conserve sodium during salt… CONTINUE READING