Role of the renal sympathetic nerves in the development and maintenance of hypertension in the spontaneously hypertensive rat.

@article{Winternitz1980RoleOT,
  title={Role of the renal sympathetic nerves in the development and maintenance of hypertension in the spontaneously hypertensive rat.},
  author={S R Winternitz and Richard E. Katholi and Suzanne Oparil},
  journal={The Journal of clinical investigation},
  year={1980},
  volume={66 5},
  pages={971-8}
}
Neurogenic factors and, in particular, enhanced renal sympathetic tone, have been implicated in the pathogenesis of hypertension in the spontaneously hypertensive rat of the Okamoto strain. To examine the hypothesis that the renal sympathetic nerves contribute to the development and maintenance of hypertension by causing urinary sodium retention, 7-wk-old (early hypertensive) and 18-wk-old (established hypertensive) male spontaneously hypertensive rats were subjected to bilateral renal… CONTINUE READING