Role of the region 3′ to Xist exon 6 in the counting process of X-chromosome inactivation

@article{Clerc1998RoleOT,
  title={Role of the region 3′ to Xist exon 6 in the counting process of X-chromosome inactivation},
  author={Philippe Clerc and P. Avner},
  journal={Nature Genetics},
  year={1998},
  volume={19},
  pages={249-253}
}
During early embryogenesis of female mammals, one of the two X chromosomes is randomly chosen to be inactivated in each cell, leading to the transcriptional silencing of thousands of genes on this chromosome. This random X-inactivation process also occurs during in vitro differentiation of female embryonic stem (ES) cells. A locus on the X chromosome, the X inactivation centre (Xic) is initially 'counted', given that at least two copies of Xic must be present per diploid genome in order for… CONTINUE READING

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