Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling.

@article{Yamanashi2000RoleOT,
  title={Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling.},
  author={Yoshihide Yamanashi and Takashi Tamura and Takanobu Kanamori and Hidehiro Yamane and Hideo Nariuchi and Tadashi Yamamoto and David Baltimore},
  journal={Genes & development},
  year={2000},
  volume={14 1},
  pages={11-6}
}
Antigenic stimulation of the B-cell receptor (BCR) is a central event in the immune response. In contrast, antigen bound to IgG negatively regulates signals from the BCR by cross-linking it to the inhibitory receptor FcgammaRIIB. Here we show that upon cross-linking of BCR or BCR with FcgammaRIIB, the rasGAP-associated protein p62(dok) is prominently tyrosine phosphorylated in a Lyn-dependent manner. Inactivation of the dok gene by homologous recombination has shown that upon BCR cross-linking… CONTINUE READING

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Role of the inositol phosphatase SHIP in B cell receptor - induced Ca 2 + oscillatory response

M. Ono, H. Okada, S. Bolland, S. Yanagi, T. Kurosaki
J . Immunol . • 1998

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