Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression

@article{Bandyopadhyay2004RoleOT,
  title={Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression},
  author={Sucharita Bandyopadhyay and Sudha K. Pai and Shigeru Hirota and Sadahiro Hosobe and Yukio Takano and Ken Saito and David Piquemal and Therese Commes and Misako Watabe and Steven C. Gross and Ying Wang and Sophia Ran and Kounosuke Watabe},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={5675-5681}
}
The differentiation-related gene-1 (Drg-1) was first identified as a gene strongly upregulated by induction of differentiation in colon carcinoma cells in vitro, and later the same gene was shown to suppress tumorigenicity of human bladder cancer cells in vivo. On the other hand, we and others have demonstrated that the Drg-1 gene suppresses prostate and colon cancer metastases in mouse models. In the context of such potential organ-specific differential function of the Drg-1 gene, the present… CONTINUE READING