Role of the purinergic P2Z receptor in spontaneous cell death in J774 macrophage cultures.

@article{Chiozzi1996RoleOT,
  title={Role of the purinergic P2Z receptor in spontaneous cell death in J774 macrophage cultures.},
  author={Paola Chiozzi and Marta Murgia and Simonetta Falzoni and Davide Ferrari and Francesco Di Virgilio},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={218 1},
  pages={176-81}
}
J774 mouse macrophages express an ionotropic receptor gated by extracellular ATP. Activation of this receptor, currently named purinergic P2Z, causes transmembrane ion fluxes, plasma membrane depolarization, cell swelling and eventual cell death. The physiological role of this receptor is as yet unknown. In the present report we show that macrophage cell clones that hypo-express the P2Z receptor showed a very low degree of spontaneous cell death in culture, while hyper-expressing clones were… CONTINUE READING

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