Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension.

Abstract

RATIONALE Iloprost is effective for the treatment of pulmonary hypertension. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). However, there is evidence that patients with severe pulmonary hypertension have decreased expression of the IP receptor in the remodeled pulmonary arterial smooth muscle. OBJECTIVES We… (More)
DOI: 10.1164/rccm.200710-1519OC

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@article{Lai2008RoleOT, title={Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension.}, author={Ying-ju Lai and Soni Savai Pullamsetti and Eva Dony and Norbert Weissmann and Ghazwan S. Butrous and G A Banat and Hossein - Ardeschir Ghofrani and Werner Seeger and Friedrich Grimminger and Ralph T Schermuly}, journal={American journal of respiratory and critical care medicine}, year={2008}, volume={178 2}, pages={188-96} }