Role of the polycytin-primary cilia complex in bone development and mechanosensing.

Abstract

Pkd1 encodes PC1, a transmembrane receptor-like protein, and Pkd2 encodes PC2, a calcium channel, which interact to form functional polycystin complexes that are widely expressed in many tissues and cell types. The study of autosomal dominant polycystic kidney disease (ADPKD), caused by inactivating mutations of PKD1 or PKD2 genes, has elucidated the… (More)
DOI: 10.1111/j.1749-6632.2009.05239.x

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