Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells.

@article{Sato2010RoleOT,
  title={Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells.},
  author={Mai Sato and Yasunori Mori and Takahide Matsui and Ryo Aoki and Manami Oya and Yu Yanagihara and Mitsunori Fukuda and Takashi Tsuboi},
  journal={Journal of neurochemistry},
  year={2010},
  volume={114 1},
  pages={171-81}
}
The double C2 (Doc2) family is characterized by an N-terminal Munc13-1-interacting domain and C-terminal tandem C2 domains, and it comprises three isoforms, Doc2alpha, Doc2beta, and Doc2gamma, in humans and mice. Doc2alpha, the best-characterized, brain-specific isoform, exhibits Ca(2+)-dependent phospholipid-binding activity through its C2A domain, and the Ca(2+)-binding activity is thought to be important for the regulation of Ca(2+)-dependent exocytosis. In contrast to the C2A domain… CONTINUE READING

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Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2013
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