Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry.

@article{Broad2001RoleOT,
  title={Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry.},
  author={Lisa M. Broad and F J Braun and J P Li{\`e}vremont and Gary St John Bird and Tomohiro Kurosaki and James W Putney},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 19},
  pages={15945-52}
}
We investigated the putative roles of phospholipase C, polyphosphoinositides, and inositol 1,4,5-trisphosphate (IP(3)) in capacitative calcium entry and calcium release-activated calcium current (I(crac)) in lacrimal acinar cells, rat basophilic leukemia cells, and DT40 B-lymphocytes. Inhibition of phospholipase C with blocked calcium entry and I(crac) activation whether in response to a phospholipase C-coupled agonist or to calcium store depletion with thapsigargin. Run-down of cellular… CONTINUE READING

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